Beilstein J. Org. Chem.2019,15, 2982–2989, doi:10.3762/bjoc.15.294
some of the acceptors. However, the Galp-(β1→3)-Galp linkage could be regioselectively installed by using some of the acceptors assayed herein.
Keywords: Fukui indexes; galactopyranosyl acceptors; galactosedonors; molecular modeling; regioselectivity; Introduction
Given the importance of
Beilstein J. Org. Chem.2010,6, 704–708, doi:10.3762/bjoc.6.80
was reduced to an amino group, which was protected as a benzyl carbamate (→ 15, 91%). Removal of the TBDMS group with TBAF then gave the tetrasaccharide acceptor 16 (89%). To obtain complete α-selectivity with 2-azido-galactosedonors is not trivial. A 4,6-silyl acetal has been suggested as one way to
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Graphical Abstract
Figure 1:
The H. influenzae outer core target structure.